NettetHuman organic anion transporter 3 (hOAT3/SLC22A8) is predominantly expressed in the proximal tubules of the kidney and plays a major role in the urinary excretion of a … Nettet1. jan. 2003 · RESULTS:hOAT3-mediated efflux of glutarate (GA), can be significantly trans-stimulated by a variety of ions with high cis-inhibitory potency, including GA …
Potent inhibitors of human organic anion transporters 1 and 3
NettetUse of proton-pump inhibitors (PPIs) is common in patients with chronic kidney disease (CKD). PPIs and many uremic toxins (UTs) are eliminated by the kidney’s tubular organic anion transporter system. In a cross-sectional study, we sought to evaluate the association between PPI prescription and serum concentrations of various UTs. We studied a … Nettet17. sep. 2013 · Pemetrexed and methotrexate transport by hOAT3 was saturated at high concentrations with apparent Km values 28.2 µM and 76.6 µM, respectively. In addition, intrinsic activity (Vmax/Km) of ... legg calve perthes disease other name
HOAT - What does HOAT stand for? The Free Dictionary
NettetMoreover, immunohistochemistry in hOAT3-expressing HEK-293 cells demonstrated that these LRD-rich proteins co-localized with hOAT3. Potassium iodide (KI), an inhibitor of … Nettet2. nov. 2013 · PCS is a substrate for hOAT1 and hOAT3, and hOAT1 and hOAT3 appear to play a physiological role as a high-capacity PCS transporter. Since hOATs are expressed not only in the kidneys, but also in blood vessels and osteoblasts, etc., these findings are of great significance in terms of elucidating the renal clearance, tissue … Nettet5. nov. 2012 · Transporter-mediated drug-drug interactions in the kidney dramatically influence the pharmacokinetics and other clinical effects of drugs. Human organic anion transporters 1 (hOAT1) and 3 (hOAT3) are the major transporters in the basolateral membrane of kidney proximal tubules, mediating the rate-li … leggat motors used cars