WebJan 1, 2012 · Some examples of hepatotoxins are given but the main emphasis is focused on the hepatotoxic dehydropyrrolizidine alkaloids. The chemical diversity of the dehydropyrrolizidine alkaloids and their complex mechanism of action following acute or chronic exposure provide challenges for analysis and toxicological evaluation. A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver. It can be a side-effect, but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids, or in laboratory environments, such as carbon tetrachloride, or far more pervasively in the form of ethanol (drinking alcohol). The effects of hepatotoxins depend on the amount, point of entry and distribution speed of the [t…

Target Organ Toxicity - Lab Safety - Grand Valley State University

WebFeb 1, 2002 · Abstract. This review addresses recent advances in specific mechanisms of hepatotoxicity. Because of its unique metabolism and relationship to the gastrointestinal tract, the liver is an important target of the toxicity of drugs, xenobiotics, and oxidative stress. In cholestatic disease, endogenously generated bile acids produce hepatocellular ... WebThe intraperitoneal application of lipopolysaccharide (LPS) alone or in combination with other hepatotoxins is an experimental model for inducing systemic and hepatic inflammation in rodents applied worldwide. The endotoxin is recognized by the LPS-binding protein. This complex binds together with the lymphocyte antigen 96 (MD2) and the … racena fischer

The MSDS HyperGlossary: Target Organ Effects, STOT-SE, STOT-RE

WebCarbon Tetrachloride Poisoning / prevention & control. Chemical and Drug Induced Liver Injury / metabolism*. Cytochrome P-450 Enzyme System / metabolism. Cytochrome … Webexample: WARNING! PHS (TARGET ORGAN TOXICANTS) WORK AREA . Substances which cause damage to target organs are considered to be toxic, and are . indicated under GHS by the health hazard pictogram and a hazard statement which specifies “damage to organs.” Specific target organ toxicity (single exposure) (STOT-SE) means specific non … WebHepatotoxicity, or liver damage, is caused by hepatotoxins, which may source from chemicals, dietary supplements, pharmaceutical drugs, and medicinal plants. Notably, numerous medicinal plants are used to ... example, galantamine, is a patented isoquinoline alkaloid that alleviates the affects of Alzheimer‟s disease via neurogenesis and race nation and class